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the best defense is a good offense... filter them to another folder and report them... get their sites shutdown, get their access removed, hit them in the pocketbook...
use spamassasin or mailwasher to filter, block, or remove the spams... i prefer to filter them to another folder and then forward them to spamcop.net for further reporting... all spamcop.net does is to tell you where the mail really came from... then you file the report by clicking the submit button...
another option is to forward them to your ISP's abuse department and let them handle them...