I hate to sit for a number of reasons, but mostly due to back issues and just being an antsy person.
I've explored standing workstations, working prone with a laptop, special ergonomic chairs, etc. Those solutions are only partial ones, as I really need my big screen and drawing tablet for the graphic stuff, and the chairs all are all over-hyped junk in my experience.
Getting real exercise should be possible, given that I work at home, but too often it's not.
For the last few years, I've mostly solved my acute pain problems by sticking religiously to an atypical posture program I adopted a few years ago and one of the nonhippie massage modalities (it does NOT feel soothing, but it helps). And these days things are far better than they were when I worked formal jobs and had to sit 12 hours a day. But I still...hate...sitting. A few minutes is fine, but hours on end....no!
What do you all do for your sitting issues? What works for you?