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Beautiful city, but high housing costs. Kid friendly, clean, fresh, great restaurants, a ton of things to do outdoors (if you can stand the rain), easy to get to the mountains, the coast, etc.
Definitely one of the best "big cities" I've been to, but I suppose that depends on what you're looking for. I'm from the Northwest, so I may be somewhat biased. :-)
The museums and galleries are great, there are lots of small and large galleries.
The rose gardens and OMSI are must-see's.
As cities go, I grew up in L.A., and Portland is pretty well managed, there is still a lot of "country" about, but it's still a city. If you're into grass roots music, you'll find lots of places to rock. :-)
The place is full of tech-geeks and Deadheads all clutching an industrial strength coffee. Stand on any downtown corner and you will find that is true.
I will be there in just a couple of weeks again.
One of the American cities I would seriously consider moving too.