Forum Moderators: phranque
You can multiple IP addresses to your server and then assign an IP address to each site. Or probably better yet, you can assign multiple sites to one IP address.
With the latter method, you must assign host headers for each site by clicking on the "Advanced" button on the "Web site" tab of the web site you have created in the IIS Manager. Then you assign an IP address, a port (usually 80) and the host header information, such as www.example.com or example.com (you should probably assign both).
And that is the main difference between running one site and multiple ones on IIS.