You must follow people who are on the same niche as you are. Look at their profile and their tweets. Also always make sure you post something relevant to your niche for other people with the same niche to follow you.
Hi indusharma, Welcome on WebmasterWorld! Did you read: An approach to twitter "How to"[webmasterworld.com ]
Trying to find relevant followers related to your biz line is also finding non related that could have interest in your range of offerings or could help your "product" web propagation. such as anchors, journalists etc... And do not forget about any others that can afford your products or services. In short establish balance.