Forum Moderators: not2easy
Your first step would be to take a look at the code generated. Run it through any of the online validators (http://validator.w3.org/) and see if you can clean up the HTML. A program like HTML Tidy [w3.org] may be able to clean out a lot of the useless code in there.
If you're comfortable with Microsoft products then you might want to consider FrontPage 2003 instead of Publisher. FrontPage is a more appropriate tool for the job.