Dig into your campaign settings and check out the demographic targeting as well. That would only affect a small percentage of the total exposure but it's one more way to tighten your targeting a bit further.
And there is much less risk involved since there is much less traffic than a full-blown national campaign. I begin all my national campaigns like this and roll them out gradually using geographic targeting since it is a very effective way to limit impressiones/clicks on placement targeted sites (content network).
Now, if only Adwords would let us geo target from the adgroup level!