And don't take it from me:
listen to what ByronM has to say
For example i've done the "bite the bullet ads" - you know, find a good keyword - that NO one bids on, bid on it only to find a 1.00 min CPC - pay that 1.00 min CPC to find out that that you're never going to get smart priced.
This guy seems to know what he's doing, [IMHO] google has an algo which determines if some keywords can be potentially profitable and slaps on a HIGH min CPC even if there are no bidders on those keyword.
What do you think?