I don't work with Adsense except on a YouTube account where it's the only option for monetization. Reason: I don't trust Google at all. I've heard too many stories about them closing Adsense accounts for reasons that aren't clear to the publishers. Years ago, rather than build up some big money through Adsense only to have Google suddenly ban me for no reason, I decided to take the safe path and use other ad providers that don't do that.
It worked, too - many ad providers pay far better than Adsense, at least in my niches.
But in 2012, Google bought one ad network I'd been working with, so I quit working with them. Then Burst Media, a long time partner of mine, jumped into some DFP partnership with them that required me to set up a DFP account or something... I kind of stopped reading because I figured the next stop would be Google eating them for a snack between brunch and lunch.
As a consequence, my income has fallen... not hugely, but enough that I'm concerned. If this keeps up, I don't know if I should give in and work with Google or at least Google-related companies, or hold out and hope... what? Clearly the FTC is prepared to let Google take over everything. Clearly none of Google's competitors are managing.
My top ad provider is looking super-shaky this quarter - even worse than some of my others. If they fold because they can't compete with Google, I'm in big trouble.
Should I just give up and work with Google, and spend the rest of my online years biting my nails all the time, or hold out and hope something improves?