Since the start of November the ads on my biggest site has been rather poor in terms of targeting. I am ads seeing that are not always highly targeted, sometimes even getting celebrity ads on what is a health site. I am also seeing lots of Adword ads, although that could have been because I had been on Adwords a few time sin the last month so they are probably aimed at me personally. But even the 'well targeted' ones are not always on the money with around 70%-80% relevance. October was awesome where the ads were perfect match and I could even see that in the CTR which was almost double the regular.