How can we reduce "Ad blindness"?

Now that multiple ad palettes is disabled.

[JCKline]

I had great success in the past choosing "multiple ad palettes" in Google AdSense, but some months ago it was disabled, even though the option is still present in the old interface.

Does anyone have any ideas on how to reduce ad blindness aside from frequently changing them "manually"? I have too many channels for that. Any suggestions?

[netmeg]

I use a PHP script to rotate them. Are you familiar with PHP?

[Atomic]

Advertisers in my niche seem to have taken it upon themselves to design creatives that look a little different than other ads.

[DaStarBuG]

You can also use an Ad Server like DFP Small Business or OpenX to rotate different Ads