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Test, test, test! When you're done, test some more. What I mean is, try different ad block sizes and colors and placements on your pages until you hit on the best combination. Follow the Google Adsense 'heat map' recommendations for placement - [google.com...]
For color, try matching the border and background on the color palette to your page's background color so the ads blend in. That works best for my sites without question.
For ad block sizes, you'll need to play around with it a lot, but really there are only so many possibilities, so you should pretty quickly discover which works best. For my sites, I use the horizontal Link Unit across the top of the page like a leaderboard and then one or two 250X250 Ad Units in the main body of the text, positioned on the left side of the page. This may or may not work for you, depending on your page layout. The point is, play with the combinations and track the results. Test, in other words. It's well worth it. You might see a big CTR increase when you light upon a good combination. Good luck!
I have a site with simliar stats to yours and added Adsense a month ago.
I experimented with 5 different ad positions and found that the best ad position gave me 4 times the CTR and a significantly higher CPC than the next best position.
So I would encourage you to experiment with different ad positions using the channels.
My next experiment is going to be comparing the effect of box and ad color on CTR and epcm.
YPN payout per click much higher (3-5X) than Google.
For us, payout per click with YPN may be higher - yes, 3-5x (am seeing the same with my sites) - but we still earn so much with Adsense since Yahoo (YPN) CTR is so much lower by 8-10x. To illustrate:
YPN = $1.50 CPC x 10 clicks = $15
ADSENSE = $0.50 CPC x 100 clicks = $50
I'd take lower CPC as long as I get more clicks anytime :o)
One thing to remember though: YPN is still in beta so they may simply be trying to sweeten the deal with the publishers by giving higher cost per click. Once it's out of the gate, it may be an entirely different story altogether. I remember the good 'ol days when Adsense was so new and clicks were still in relative stratosphere, only to come crashing to earth a couple of years later. CPC is still good, but not as good as when it just started.