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The site I'm running AdSense on is a destination-specific travel site - I've blocked ads relating to other destinations, especially destinations greater than 12,000 miles away from mine. Perhaps I get less of a chance to gain revenue, but I'm also not annoying my users with ads that are completely unrelated to what they're looking for.
I've even listed several versions of the URL to filter (with the www., without the www.) etc. but nothing works.
I'm too lazy to eliminate and figure out which one it wants.
I blocked them because they showed top stop on each page, booking realted and they have an affiliate program... I signed up with them, it was something I was looking for anyways. ;)
(Believe me, there is nothing "official" about the site I'm trying to filter; it's inappropriate, especially for the pages it's appearing on, and it's driving me crazy that I can't block it.)
I emailed AdSense and they forwarded the issue to their engineers. A couple days later I got an email saying that their engineers are working on resolving a problem with the filters.
They said that they have a temporary fix in place that will update the filters every 24 hours or so. They're working on a permanent fix. I'm pleased with their responsiveness on this issue.