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Anyone else having any issues?
Do you already have section targeting? If so, you might be focusing on text that it's picking up on inadvertantly? In my brief experimentation with this, I found that having no section targeting at all worked best for me.
You might find that re-writing the page helps targeting, and avoiding or rephrasing words or phrases that might be triggering the wrong ads. Maybe the count of certain keywords is too high / too low?
I have had an instance where there were no changes to the page, but the bot decided to show totally irrelevant ads. I did email Google on that ocasion and it was resolved, but as a rule irrelevant ads are going to be due to page content, and it's necessary to modify the page accordingly.