It depends on the type of site. In our case we tend to target a primary keyword and a few [less than 10] two worders, three worders take care of themsleves. With this stratagy Google falls to 3rd or 4th place, still important but not make or break.
Among other things, Google glitches have convinced me to
1) develop more mini-sites rather than putting all my eggs in one basket, domain-wise
2) get serious about developing a newsletter
3) test some offline advertising.
The challenge is to develop a broad enough base to provide some stability during Google's ups and downs.