Thanks,
Daniel
Automatic indexing will occur in regionals and more weight is given to domain names that have "co.uk" (for UK regional) but this doesn't mean you get a top ranked position and ".com", ".net" etc. if relevant can equally get to #1. Other than this, the general algo still applies.
The single greatest "tip" for improving regional results, is placing your physical address on every web page particularly if offering products and/or services. If text is impractical add to "alt" tag or a title element. Many people type in "toys+UK" or similar geographical queries.