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In what ways do you think they're different?
Which one provides better more detailed reporting?
Now that I've gotten to know Omniture (which has taken several months - its huge!) I much much prefer it.
It is so easy to set up customizable variables, tracking codes, and there are so many ready-made reports that Google just doesn't offer.
I can accomplish a lot more in a small amount of time than with Google.
Although I should say that I still use only Google Analytics for small sites. Like, less than 100 pages.