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Advertiser's domain is listed on some hacking and malware pages...
Choosing the "hold ads" setting may also decrease your revenue, because ads that are awaiting review won't participate in the auction either. Please consider the potential revenue impact before choosing to hold ads rather than running them immediately.
Doesn't mean they are going to win the auction and actually appear on the site if they are that far off topic, because the ctr would be awful, no?