Broadway - 5:23 pm on Mar 5, 2013 (gmt 0)
I'm in the process of switching to a responsive design. There are some great points brought up here.
I have to assume that this has been discussed before (I don't get to WW all that much to read) but in my opinion Adsense has already developed the answer to the problem of serving ads to smaller-format screens. It's the large arrows that are placed in ads.
On smaller devices they simply look like navigation. You can't read the advertising text so, as a visitor, you don't really know, you just click.
This behavior is especially appalling with leaderboards and skyscrapers where the amount of advertising text is left small (top or left side of add) and the arrow is positioned as far away as possible, once again making just look like website navigation, not part of an ad.
My absolute first foray into responsive design (used with my fixed-width site) was to detect browser size so the size of my own page's navigation could enlarged compete with the adsense arrows.
Just yet another example of Google/Adsense hypocrisy.