I wish you well. These are tough choices for anybody.
I've worked alone at home for nearly 20 years now. The isolation can be daunting if one doesn't like being alone all that much. I've made a habit out of getting out of the place and away from work by just going out for coffee, etc., and chatting up the weather or whatever with whoever happens to be at the coffee shop.
Fortunately for me, the nature of my niche also dragged me joyfully out of the house and around the country to niche events where I got to hang out with others with similar interests.
But after 12 years with the website I'm beginning to look longingly at the grass on the other side of the fence and pretending it actually looks greener (just back from a road trip through Indiana, Illinois and Iowa, the fields are pretty much toasted).
Anyhow, it sounds like you've thought this through pretty well, so I hope it all works out as well as can be for you.