IanCP - 11:42 pm on Mar 12, 2012 (gmt 0)
i think the worst mistake that people make is that they think of a subject, before they think about the ads.
I totally disagree. The internet has been totally debased by AdSense and other affiliate programmes.
The theory of having a site about something you are passionate about and can effectively record your knowledge still rings true [unless dopey Panda doesn't like it].
A good, knowledgeable site is still the way to go. By all means make it SE friendly, solely because it is easier for people to find.
A site made with AdSense [or anything else] in mind will always be a site with AdSense in mind. The amount of MFA I have to drill down through today, compared to ten years ago, is utterly appalling.
Write about what you know best and love.
The only valuable suggestion I can offer, in retrospect after 15 years, is learn Server Side Includes or SSI. Someone will no doubt suggest something they think better.
SSI allows you to alter one text file and, as with CSS, one simple small change becomes site wide, including the ads you present.