I used to make a good income from Adsense until (a) I started to make too much and (b) my click-through rate got to be too big after which Google turfed me out, no discussions, no second chance. I now make a better living dealing directly with companies that once bought Adwords but either got kicked out (again no explanations, notice or discussions) or got fed up with paying a fortune for phantom clicks (You every tried querying these?).
So sure, go with Adsense if you're happy dealing with a company like Google. You'll read enough experiences of other people who trusted them to make your own decision.