koan - 8:25 am on Dec 29, 2010 (gmt 0)
have been eroding my ctr over the past three years or so
I have to say this is my main problem also... serious CTR decline in roughly the same time frame, among many different sites, topics, traffic and layouts, with a historical record low this past november-december. I'm not convinced it's ad blockers though, I think it's a mix of ever more restricting methods that Google use to count real clicks and Adsense being on every crappy sites out there, leading to ad blindness.
My strategy for 2011 will be to redesign some sites and use bigger ad formats, even if it degrades user experience a bit (last pieces of idealism slowly eroding away, lol). I guess they're not leaving me any choice.