We just got the new layout on our site this morning. So no stats on performance yet, but it looks okay. The 336x280 ads with appended URL to the title don't wrap, so that is nice. The URL just cuts off at the end instead of wrapping. Gives the ads more whitespace between them.
The 736x90 changes definitely take some getting use to. They look very different on our site. We had to add some spacing after the ad unit on some pages to make it look better since it was looking over-crowded.
Looking forward to see how they perform.