primal5 - 8:59 pm on Mar 6, 2008 (gmt 0)
When I first started I was using Adwords Editor a download directly from Google Adwords. Very useful and offers all the functionality you need. I actually managed multiple campaigns with it no problem. You can set rules for individual keywords all the way to your ad campaigns.
You can download your adwords statistics and compare which words are doing we'll and find the bad ones out the bunch, and make multiple changes to them at once. It also allows you to make multiple changes at the campaign level or specific keywords. It also allows you to set negative keywords by specific ad groups or at the campaign level.