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justdave - 8:30 pm on Jan 22, 2007 (gmt 0)
To me, Google will be your best option. a combo of Yahoo/MSN may be a good alternative. I don't know how detail-oriented you are with your campaign on Google, but I assume you are at least tracking conversions. If your conversion/conversion rate/cost per conversion are too high, have you performed any strategic optimization? I don't want to presume too much on your campaign, so I will just leave it at this. In my opinion, many PPC campaigns "fail" in the eye of the advertiser because they are not systematically and continually optimizing their campaigns.
Since your site is general, as you say, I would guess you'll need to avoid niche ppc engines. If you want low cost/click with high traffic, you'll have to dig.