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incrediBILL - 12:59 am on Oct 26, 2008 (gmt 0)
Other software may also have vulnerabilities but nothing I've ever read about has the same level or even comes close to comparing to the hacker friendly Swiss cheese holes of WordPress and/or it's plug-ins. Your safest bet is no WordPress whatsoever. [edited by: incrediBILL at 12:59 am (utc) on Oct. 26, 2008]
The best way to avoid a hacked WordPress site, if you must use it, is let WordPress themselves host it. For a very small annual fee the blog will even appear on your domain name and they have it secured, no threat of your server being hacked.