GodLikeLotus - 2:52 pm on Aug 13, 2011 (gmt 0)
We run sites in Australia, Canada, UK and the US, and the issue of spelling is extremely important, if you do not want to upset some of your visitors.
A couple of years ago, we did not REALISE the importance of using the word "Inquiry" and not "Enquiry" on our contact form page on a US targeted site. We had this pointed out by several visitors, and so made the changes.
I am English and was moved to the US in the early 80's by my parents, where I was enrolled in high school. One of my favorite stories was asking my 30 something, female math teacher if she had a "rubber" I could use. Luckily she understood the different meaning of the word, but the rest of the class, it was the funniest thing they had ever heard.