dstiles - 8:40 pm on Oct 9, 2013 (gmt 0)
I use wine only in extremis. I do not trust anything that requires any MS environment. I don't distrust wine as such but some VM ware running on linux was recently found to be tainted. But for real compatibility I keep an off-line windows machine on the network accessed via RDP.
I really urge anyone who is serious about their computing to subscribe to the threatpost feed (or read the web site). There are a lot of nasties aimed at both corporate and home systems which, when investigated, can be laid at MS's door; and not a few at Apple's pit (and many, many compromisable mobiles starting but not ending with Android!). But there are also a few linux compromises from time to time, as I noted earlier.
diberry - later Macs are indeed variants on unix, but without the robustness of the open linux system. Macs are not as vulnerable as windows but they are still virus targets and linux has far fewer exploitable vectors.
As to MS Office, the one thing I need that linux cannot manage is Access/MDB compatibility and that is insurmountable.