I've tried to get a site out of a manual penalty for nearly 18 months now. 5 or 6 RRs, all rejected (all with link removal efforts before). The 2nd-to-last notification I got from Google had 3 example links. I removed those plus more that were similar in nature to those examples, submitted a disavow text file for the links I could not remove. I submitted my last RR and got a reply back from Google saying I still had unnatural links and they did NOT supply examples this time. Absolute last straw for me. There surely has to be some kind of marketing revolution going on - who would rely on a marketing channel that's so hostile to simply doing business? There are many other channels out there - you need to work harder in these channels, and maybe you need to kill that business model that relied on passive, high volume traffic, but many business models (services, higher value products) can be sold outside of Google.