Yeah, I'm definitely seeing some oddities and differences.
One thing I've noticed that really makes me think there is a datacenter alignment issue is I've had site: searches changing page count throughout the day for the last few days.
The real "tying together" point for me though is when traffic is down, it's up overall due to expansions, but when it's down on an hourly basis relative to the previous week or year, I get a lower number of pages when I do a site: search. When it's up the site: search is "at it's peak" for pages indexed.
I've definitely also seen a shift to "location specific results for generic queries" in place since Sun/Mon and it might be that "rolled out" earlier (like Fri) into different sectors earlier than the ones I normally watch.