smithaa02 - 2:28 am on Nov 3, 2012 (gmt 0)
Not to be nitpicky...but this isn't some run of the mill hack. It is the official recommended implementation from wordpress and is very common (any wordpress site that doesn't have index.php prefixed in the urls is using this).
Sure, this can be done. If you know what you are doing, you can achieve just about anything with mod_rewrite.