I have on exact-match-domain.co.uk in the travel industry NOT yet hit, though not in hotels or flights. Has been a busy site with a useful function for the public for many years. A fraction of the revenue is Adsense (<1%). If it gets hit or not, I'll reveal all at my Affiliate session at Pubcon :)
Not sure if the sites below me are "better". But maybe time to up my game on this one.