I am slowly and officially abandoning my main site. Weeks turn into months as I'm waiting for something positive to happen while doing small improvements trying to figure out a reason for a minus 950 by Panda and the dropping positions. It has wasted a huge amount of my time and money. If G decides it doesn't like your site anymore (Pagerank drop, rankings drop, 950 filters to content that ranked ok for years etc.) then there's not much you can do to get the love back.
I feel for everyone of you in the same boat.