Reno - 4:34 am on Jan 6, 2012 (gmt 0)
There's less to lose if you spread your efforts across multiple domains/sub-domains whereas if everything is on a single domain with a normal folder structure Panda will wipe you out entirely.
This is how online marketing will increasingly go now that we're firmly entrenched in Pandaworld.
As was mentioned in an earlier post, with the Panda virus seeming deadly to most webmasters, there will be even more websites with even more redundancy from now on, as serious marketters play every angle, hoping that one of them will escape Panda's fatal glance. It's a cat & mouse game, and for every mouse that Google catches, 3 more will come along, and so it will go, because there's a LOT more mice than that cat can ever kill.