Freedom - 3:50 pm on Sep 7, 2011 (gmt 0)
My humble prediction,
I expect part or some of a new algo will go after keyword domains, because they already said they would. And whatever they do, there will be collateral damage, because there always is. I could also see some targeting of anchor text links, and paid links.
Keyword domains, with hyphens and without, have enjoyed an advantage post Panda and I expect that to be taken away. And Brett mentioned Florida, not Panda. If you remember Florida, it was all about beating down reciprocal linking and anchor text manipulation. Since reciprocal linking is dead, they'll roll up the link game with more sophisticated targeting this time.
That's my opinion.