Errioxa - 10:18 am on Jul 15, 2011 (gmt 0)
From Spain we search in Google.es (99%), but Latino users uses .mx.com .cl etc.
I don't know US Hispanics users :(
If your users are US and South America I think that .com is better.
I have many sites .com (US Ip). South America traffic is good, all content is in spanish.