albo - 3:28 pm on Feb 22, 2011 (gmt 0)
I sort of agree with @maximillianos... It's a real pain to poke in all the @media declarations for mobile devices, but worth a try, if nothing else but for entertainment, perhaps. One has to deal with not only various resolutions but also (on some devices) on-portrait and on-landscape! Best to leave a choice.
Single-column has been the easiest (a cop-out) for me, with large, collapsing/expanding menu bars a la Google mobile. But that's rather annoying for e.g. iPad users: they need a choice.