Hugene - 7:30 pm on Jan 31, 2011 (gmt 0)
I remember reading an invaluable advice here on WW: never start your Title with your domain name.
And it makes sense: why waste title real-estate when the domain name is in the SERPS anyways.
So instead of this title:
MyWidgetPage.com: all the info on red widgets
do it like this:
All the info on red widgets, by MyWidgetPage.com
It might not even be needed to have your domain name in the title, but if you have keywords as domain name, I think it is good to have it.
Also I think titles should be readable, follow a correct grammatical structure, and thus include words such as "the" "a" "with" and whatever else you need.
Having synonyms, without the main keyword, are not a good idea. Ex: "Red widgets and widgets synonym info" is better than just "Red widgets synonym info".
Basically, make sure that you have the exact keyword you want to rank for as close as possible to the start of the title.