Webwork - 7:52 pm on May 18, 2013 (gmt 0)
If you don't address your registrant by their name you probably are increasing the odds of being ignored. When someone contacts me and cannot even bother to address me by name (it's right there in the WhoIs) then I assume they either aren't really that interested OR they aren't that sophisticated in matters of business and/or domain acquistion.
Address your hypothetical seller by name and do consider making an initial reasonable offer. Odds are very good that your offer will not exceed the theoretical seller's expectations ... but your offer will show that you (may) possess some domain intelligence/savvy and are prepared to do business.