Webwork - 1:02 pm on Jul 22, 2011 (gmt 0)
If they want to sell and YOU have the money YOU can insist "Deal . . . or NO deal" on using Escrow.com. In the business deal making world you need to have a very strong "I can walk away from this" mindset before entering into a negotiation. Otherwise, don't bother negotiating and just present your terms . . and walk away, if need be. (There is a subtle distinction. One is "the appearance of indifference". The other is necessity, reality, limits or whatever you may call it. YMMV with the approach you choose in any situation.)
I know of no "no risk" human engagement but Escrow.com has never failed me, nor anyone I've come across (as a domainer) in the decade or so since they've been in business. They do a pretty good job of assuring the money is in the bank before saying "transfer the domain".
I don't know about other escrow companies as I tend to stick with what works by experience and by (widely held) reputation. That's not to say there isn't or there shouldn't be room for competition . .