virtualreality - 8:30 pm on Aug 12, 2010 (gmt 0)

Ok I am hesitating between two domain names -

SomethingMyKeyyword1MyKeyword2.com
or
MyKeyyword1MyKeyword2Something.com

I like the first one better "SomethingMyKeyyword1MyKeyword2.com" because it makes more sense but I am considering "MyKeyyword1MyKeyword2Something.com" because it starts with my two keywords.

Do search engines care where keywords are placed in a URL? Does the first keyword has to be the one that is the most important in a URL?

Thank you!