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buckworks - 6:28 am on Jan 2, 2009 (gmt 0)
The latter might convey some advantages for specific SEO goals, but in many cases such a domain would be seriously limiting for broader business goals. My opinion: go for a domain name that would be brandable and memorable, and learn how to use keywords effectively in directory names, file names, subdomains, etc.
Few of us ordinary mortals would have the budget to obtain an "industry defining" domain name; we'd have to settle for something like some-convoluted-keyword-phrase.tld if we want a keyword rich domain.