robho - 5:26 pm on Sep 1, 2007 (gmt 0)

Depends what you call major, but I've always used Paypal for domain transactions up to a few thousand dollars, both buying and selling, without any problems (although maybe I've just been lucky).

Most of my larger sales ($5k+) have been via brokers but for direct sales of that size I've used escrow.

Perhaps the key point is your sale listing should have specified how you accept payment. It's not something that should be decided after a sale is agreed. Paypal is just about standard, unless something else is mentioned.