pbradish - 9:26 pm on Mar 7, 2013 (gmt 0)
There's some out there like Demandware and their competitors. They start at $60k/year with a one-time $xxx,xxx install fee. Big corporates use them like Adidas, Crocs, Land's End, Pacsun, etc.
Others like Nike are on Magento Enterprise Premium. They will run you $50k+/yr.