ergophobe - 6:22 am on Oct 11, 2012 (gmt 0)

I use Ubercart. I would probably use Drupal Commerce, but I only use those because I can leverage existing Drupal skills. Barring that, I would go for one of the major carts, possibly one of the hosted solutions like Business Catalyst or something like that so I wouldn't have to deal with all the hosting issues.