I'm in Virginia but many of suppliers are in other areas. Centrally, Michigan and Indiana are really good - goods get to Virginia via UPS in 2 days. Also from Michigan many west coast states are 2 days. Louisville might be a good option too. UPS has their big hub there (Zappos locates there warehouses there too) and the cost of living is not bad. You are also only a few hours away from several other major metropolitan areas - if that is important. Chicago, Cincinnati, St. Louis, and Nashville are all an relatively easy drive away.