IMO, the beauty of an online biz is that you can live wherever you can send out and receive deliveries, which takes in a lot of ground. I like upstate NY because it is beautiful and cheap and NYC is four hours away. Shipping is pretty good here. If I mail a priority mail box to CA, it goes up to Rochester that night and is often there the day after. Longer to FL or TX. People complain about the taxes here, but they have never seen the taxes in IL, I think.
Anyway, if you are thinking of relocating, choose a place you really like.