digitalv - 3:38 am on Mar 9, 2011 (gmt 0)
Pretty sure there is a hosted cart out there that lets you run multiple stores that run on different domains & different looks, but against the same product database. That would be ideal.
The down side to scripts is that once you customize it (which you would have to for the type of thing you're talking about) those updates might not work. I can't think of a hosted cart that does what I just described off the top of my head, but I know there has to be one, they've thought of everything else.