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Corey_Bryant - 11:48 am on May 1, 2007 (gmt 0)
First - figure out if you want a hosted solution or a cart on your own site. Usually on your own site is better because you have a bit more control over it. You can usually easily move it to another hosting company if something were to happen. Then determine what language you would like and what database. Then figure out what all you would like to offer (i.e. real time shipping, what taxes to charge, affiliates, etc) and see what carts might be able to offer those add-ins. -Corey
Of course there is not such a thing as best - this would imply it makes everyone happy, which is impossible to do unfortunately.